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| · Company： |
FHPEE engineered products co., Limited |
| · Add： |
Lishi Economic Development Zone. Fushun city.Liaoning Province China |
| · Tel： |
0086-24-56109606 |
| · Fax： |
0086-24-56110547 |
| · E-mail： |
leo.sweezer@hotmail.com |
| · Code： |
113123 |
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Improve Glass-Lined Reactor Efficiency with Safe, Effective Cleaning of the Reactor Jacket |
INTRODUCTION
Glass-lined reactors are used in virtually all of the world's pharmaceutical manufacturing facilities. There are several key reasons for their selection by design engineers.
In a pharmaceutical process, cleanability is critical. Between batches, each reactor and its associated process equipment must be thoroughly cleaned in order to assure product quality and minimize heat transfer resistance caused by product buildup.
Fortunately, glass has a high degree of surface smoothness which makes it easy to clean using noncorrosive, low pressure cleaning systems . Glass is also chemically resistant and as a result, can serve for many years in environments that would quickly render most metal vessels unserviceable. Aggressive reaction environments also tend to dissolve metals from unlined mild steel or alloy reactors. These metals can compromise product quality in an industry where purity is essential. By comparison, the glass-lining protects the base metal so effectively that the relatively benign heat transfer fluids used in the jacket space will generally attack the jacket and reactor exterior long before the reaction environment compromises the glass-lined interior of the vessel.
The technology certainly exists to minimize corrosion in the jacket space , but it is not often implemented. There are many reasons for this but the major factor is that productivity is usually a higher priority. Reaction schemes are designed to be as brief as possible in order to maximize production. From the standpoint of corrosion and deposition, it would be ideal to have one properly inhibited fluid that could serve as both a heating and cooling medium. However, there are faster methods of heating and cooling. Steam is commonly used because it heats reactors very quickly and water is used for cooling because it cools reactors very quickly. For rapid chilling to lower temperatures, there are mechanically chilled glycol solutions or salt brines.
CONCLUSION
Glass-lined reactors are widely used because they work where lesser materials simply fail. In the quest for optimum production efficiency, jacket space corrosion and deposit control are frequently neglected or forgotten until problems arise. Corrosion and deposition result from the high temperatures, low flows and variable operating conditions within the jacket. Resulting fouling robs the production process of efficiency. Heating and cooling times are extended and product quality can be compromised. Traditional methods of reactor jacket cleaning are risky or ineffective. Acidic cleanings put the reactor's glass lining at risk for fishscaling damage while alkaline cleanings do not effectively remove iron and calcium based deposits.
A novel, neutral pH cleaning program has demonstrated the ability to improve plant reactor efficiency significantly. It does so by removing mineral deposits without risking damage to the glass lining or the reactor base metal and is recommended by the major manufacturers of glass-lined equipment as the only safe and effective means of glass-lined reactor jacket cleaning.
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